31 Aralık 2012 Pazartesi

2013 what predictions? Eh Sherpa

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Ok. I just put this here because I like Andrew Dice Clay. Here's my take. Let's look at what happened in 2012 and my predictions.
Here's what I said

1. In regards to DTC Genetics, the FDA won't shut you down if you are google.But you will have to give your test away for free to build your database

If 99 dollars isn't giving it away, I have no clue what is


2. In regards to Pharmacogenomic testing, most doctors won't use the service despite studies showing utility that have existed for 2 years.


They still didn't in 2012.
3. In regards to GWAS predisposition testing, it is mostly useless. It doesn't scare or heal you.......most of the time


Nothing has changed science wise with this statement

So Now, after months off I have to come up with brilliance. Really?

Navigenics=Dead DecodeMe=Dead Pathway=Weight Loss genetics 23andMe=Giving tests away next to free

DTC Genomics is not the play here. 

For personalized medicine to succeed, the clinicians still need to learn and the students need to teach.

Prediction 1. A true 1000 USD genome will come out in 2013, late November, early December

Prediction 2. Someone will sue 23andMe for privacy violations

Prediction 3. A big set of PGx data will be released....and ignored.

Prediction 4. Hillary Clinton will have either cancer or a stroke. Her health reports are suspect at best.

Prediction 5. Nutrigenomics will begin to have much more press coverage.

The Sherpa Says: I am here, blocking and tackling. Awaiting the next phase of the climb. 

Dealing with other people's pregnancies

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This is something I've been asked about a few times, and something I was just thinking about, so thought I'd share. In the months after Joshua's death, some people were hesitant to tell us they were pregnant in case they upset us, some tell us before anyone else because they want to tell us in person rather than on the grapevine. That really didn't bother me, I'm generally excited to hear about friends pregnancies. Ultrasounds were hard to look at, and baby showers were hard to go to, and still are. Joshua died 2 days after our baby shower, so baby showers just don't have that same level of fun anymore, memories of our loss just come flooding back.

The other thing that's hard to deal with is other people's loss, but for a slightly different reason - my heart just aches for them. A very close friend had an early miscarriage a few months ago, and my heart ached for her. Another good friend who has also had a rough year has just suffered a 2nd trimester loss, and it breaks my heart. I don't want anyone to ever feel the weight of loss like we did. I know a loss earlier in the pregnancy is probably a bit easier to deal with, but it's never easy, and once you start planning names, planning how the room will look, what you'll need, changes you'll need to make, and start thinking about the future they're going to have, it's so hard to have it all ripped away.

It's something that really affects you for a long time, and I think it's important for people to understand that.

Catching up (yes I'm still alive)

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It's been a really busy few months! I'll go back to September.

We went on holiday to the Seychelles and Dubai for 2 weeks in September which was fabulous. My aunt Vicki lives there with her husband Chris and their two boys, Jack and Harry. Chris has a job as part of the United Nations, which is based in the Seychelles and they've been living there about 4 years now.

The Seychelles was fascinating. The economy is completely broken - they have the highest level of debt of any other country, and since we were there the International Monetary Fund has agreed on a $26 million rescue package, and the currency has floated and been devalued. A lot of things were run down, the roads were terrible, there's a big divide between the rich and poor and everything has to be imported, so the black market is rife.

But the beaches were gorgeous, the weather was fabulous, the sky was oh so clear at night, and the stars were stunning. Sitting out on Vicki and Chris' deck every evening watching the night sky was an amazing way to relax. We were a very short walk from the beach, and just enjoyed our 10 days there relaxing.

It was great to spend quality time with Vicki, Chris and the boys. Vicki lived with us for a few years when I was younger, so I've always felt very close to her, and Jack and Harry are such great kids, we had a lot of fun with them.

Here's a few pics from the trip:

The markets



Amazingly clear water



Full moon over the fishing boats that were at port due to the worries over the Somalian pirates



We hiked to a beach called Anse Major, which was quiet, and so pretty



On our way to Anse Major




View from Vicki and Chris' balcony



Everyone. Vicki doesn't usually look so grim, and no, Andrew didn't bother with shaving while away :)



A couple of gorgeous sunrises







After Seychelles we spent a few days in Dubai on the way home since we were flying with Emirates (best airline I've ever flown with by a long shot), and stopping in Dubai anyway.

It was Ramadan, so we couldn't eat or drink in public during daylight hours, and a number of places were either closed for the month, or closed for a few hours in the afternoon, but it wasn't a big deal. We had a really nice hotel which we got a great deal on due it being Ramadan, and therefore the low season, the city in general wasn't too busy, and we just did a double decker open top tour bus tour the 2 days we were there, which supplied us with complimentary cold bottles of water which we guzzled as soon as we got on the bus - so we probably drank more water than we would have otherwise.

It was stinking hot - over 40 c, and about 90% humidity, and the heat was disgustingly oppressive. We had a fabulous time though. It was such an interesting place, and there was so much to see and do. And being so hot, it made us very aware that we were in a desert, and the regular calls to prayer from the temples made the whole experience more authentic. It's a place I would like to go back to some time to further explore - 2 and a bit days definitely wasn't enough!

Some pics:

Down on the water - there were boats coming and going loading up with goods to be transported to other nearby countries, carrying tourists around, and general water taxis for transport.




A small selection of gold in one of the windows at the Gold Souk (market)



A shopping centre called Wafi - it had designer shops, and an upmarket "traditional" souk area - the place was deserted due to Ramadan, and most of the shops weren't opening the entire month.



One of the water taxis



Dubai is a construction zone! There were cranes everywhere you looked. The sky was never clear, it's pretty much one big sand storm. And this highway made American highways look tame!



The new Metro system they are building which will make a huge difference to traffic - you can see Burj Dubai in the background which will be the world's tallest building



In front of Burj Al Arab, Jumeirah - the water there was toasty warm!



And then Ski Dubai... so bizarre!



One of the big mosques



One of the mosques near us. They were having the evening iftar buffet (breaking of the daily fast)



And Andrew on Dubai Creek at sunset



The rest of the photos are here

I'm a Golden Retriever!

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According to this website, if I was a dog breed, I'd be a Golden Retriever :)

What dog breed are you? I'm a Golden Retriever! Find out at Dogster.com

Yep, sounds like me :)

Golden Retriever

The Charmer


Laid-back, sociable and well-groomed, you've got your own hip little pack of groupies who just love to be around you. You have a brain inside that adorable little head of yours, though you use it mostly to organize your hectic social calendar. You never poop out at parties, and since you're popular with ladies and men, as well as children and adults, you dish out your wit, charm and luck to whomever is close enough to bask in it. The top dog likes you and wants to be your best friend, despite the fact that he doesn't really know what the heck you do. No one does, in fact, but everyone loves you all the same. A true foodie, you’ve got your keen ears fine-tuned to make sure you don't miss out on the opening of a trendy new place to nosh. But your youthful days of being able to wolf down food 24-7 are wagging behind you, meaning you've got to watch what you eat so you don’t pull a Brando and outgrow your coats.

The kitties and their Valentine's Day dates!

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The girls had a lovely time for Valentine's Day. They all had very handsome dates, and they dined on caviar, drank the worlds finest milk, and indulged in some catnip to top off the evening ;)

This is Lily, my middle girl, and her date Stoli, a handsome Russian Blue





Smudge, and her date, Luxor who is an Egyptian Mau.





Stoli and Luxor are brothers and best friends, and Smudge and Lily are sisters and best friends, so they double dated :-) Their mum, Renovia, does amazing art work, particularly cat sculptures, so check out her Etsy store if you're looking for a good present.

And last, but not least - Stumpy and her date, Dorian Grey aka Dorky. They make a good pair!


27 Aralık 2012 Perşembe

More revolving door antics with Obamacare

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I have commented before about the happy feet of Elizabeth Fowler and her travels in and out of government and in and out of the industries materially affected by the branch of government in which she "served".See here for earlier commentary.

Now a similar tale can be told in regard to a major player in the governmental regulation of the health  insurance industry.Steve Larsen's resume is similar to Dr. Fowler. As outlined here he worked with an insurance company and then played a key role in HHS  dealing with insurance regulation as regards ACA and now back to insurance, this with a subsidiary of a company who was the beneficiary of a large HHS contract while Larsen was employed by HHS.

Larsen left his position as head of HHS's Center for Consumer Information and Insurance Oversight shortly before SOCTUS ruled Obamacare was constitutional and is now an executive VP with the UHG subsidiary Optum. Mr. Larsen also played a role in one of favorite examples of the social justice brought about by Obamacare,the granting of exemptions to friends of the administration. See here.


The Tenth Commandment and Hayek were right about envy

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Quotes for the day From FA Hayek and PJ O'Rourke bring a year-end message about envy and social justice.

Quoting  the economist, Anthony de Jasay quoting Hayek.

"No effort to make society drabber will make in drab enough to relieve envy. Hayek,invoking Mill, pleads that if we value a free society, it is imperative 'that we not countenance envy, not sanction its demands by camouflaging it as social justice, but treat it.. as the most anti-social and evil of all passions' "

PJ O'Rourke, whose scholarly credentials include having actually read  Smith 's Wealth on Nations in the original English, has this to say about the envy and coveting things:

"The Tenth Commandment sends a message to all the jerks who want redistribution of wealth, higher taxes, more government programs, more government regulation, more government, less free enterprise, and less freedom. And the message is clear and concise: Go to hell."




References:

Page 198. The State, Anthony de Jasay
An Alternative Inaugural Speech" (18 January 2005) by PJ O'Rourke

More and more physicians work for corporations-what could possibly go wrong?

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Dr Roy Poses tells us that plenty can go wrong and has already and will only get worse. See here for his latest commentary  of things going wrong when physicians' salaries are dependent on hospitals and other corporations for their livelihood who in turn exists to maximize profits and "quality care" is just a marketing phrase.


This detailed article from the NYT provides more chilling documentation of what can happen and,is happening, as corporate entities practice medicine and physicians become more and more under the control of the corporations' suits.


When there is a conflict between the corporation's bottom line and the individual patient's well being one could only hope that the physician's ethical compass would point in the direction of the patient benefit.However, with the new medical ethics , one could argue that the good of the collective ( the HMO or ACO or hospital  or whatever) may well trump the welfare of the individual .

 That was not the case with the "old ethic" in which the good of the collective was not mentioned and the physician was considered the fiduciary of the patient.Try and find the word fiduciary in the New Professionalism or in the latest edition of the ethics manual of the American College of Physicians.

When the physician and the corporation have the same interest  (corporate bottom line) and the former act in the interests of the latter the published desire of Berwick and Brennan to do away with the [physician - patient ] dyad as a decision making unit will be fulfilled. See here for my earlier comments on the following quote from Berwick's Book entitled New Rules.

 
"Today, this isolated relationship[ he is speaking of the physician patient relationship] is no longer tenable or possible… Traditional medical ethics, based on the doctor-patient dyad must be reformulated to fit the new mold of the delivery of health care...Regulation must evolve. Regulating for improved medical care involves designing appropriate rules with authority...Health care is being rationalized through critical pathways and guidelines. The
primary function of regulation in health care, especially as it affects the quality of medical care, is to constrain decentralized individualized decision making.


In the 17 years since the publication of New Rules,considerable progress has been made in their desired reformulation of ethics and how medicine is practiced and one can surmise that the authors are appropriately gratified. Those of us who hoped that in our hour of medical need we would be attended by physicians who acted in their fiduciary duty to us and not in accordance with a reformulated ethical framework are a bit less sanguine.

23andMe Buyer Beware, The Internet doesn't equal hippocrates

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Ok, ok. I am not gonna tell you I told you so. But, I did.
Did anyone read my article in Nature Biotechnology? Did ya? 


Here is your freaking reality check. 23andME has your DNA. It has it hostage and it has your datapoints. And it can do whatever the hell it pleases. Including locking or cancelling your account.


They have enough data points for their robust database. They only need you sheep to keep paying 9 dollars per month or 108 dollars per year and 99 to start. 10 years? 1080 dollars. Even more than the first 999 USD they started with.


Well guess what? People everywhere are waking up to the charlatanism that was peddled by Silicon Valley Overlords.....


They have you, you are stuck. You have to pay FOREVER!!!!! BWAHAHAHAHAHAHAHAHAHAHAHA!!!!!!


Even if you quit, they don't care. They Pwned you. And they still do. 


So what did the Sherpa say all of those years? Huh? No, not that their health reports are bull $hi!. But I did say that. No not that I was done posting on 23andMe. Clearly I am not.


But I told you about the Master Plan!


Even if you pull out your data, they still have it. End of story. You are powerless and have been duped. I am sorry. I wish you had listened


The Sherpa Says: Buyer Beware web sites giving you tests and testing your DNA. 23andMe and its company are not  to be trusted. Sorry, but the web has not  take the hippocratic oath!


What's the Sherpa Up To?

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I have decided to write an update to what the Sherpa is Up To. Why? Well, after 5 years of hard work, Lee Gutkind is about to publish a work of creative nonfiction. I am one of the main characters. The other characters are also very compelling. 


I was able to preview a copy and am very excited. 


But, after reading, I thought I should give you an update on what the Sherpa is doing. Let me explain my madness. Here is my thought. As my good friend John Setaro MD would say. 


"There isn't any genetic advantage that can't be overcome with aggressive environmental modification."


This was me. I was overweight, the practice was stressing me and killing me. I needed to lose weight. I did. 30 pounds of weight. Mostly fat. This changed my life. How did I do it? FitBit, metabolic testing using gas exchange, calorie tracking, some things that a guy like Eric Topol MD would call mobile health.


I began to pay attention to obesity. I noticed that obesity is a huge familial disease and an epidemic in the US. But, the genetic markers soft at best. So I say again, family history matters more. I studied fat metabolism and began to realize this disease was very similar to some mitochondrial deficiencies. I began to align genetics, family history, obesity and preventative care. Truly personalized medicine. I will sit for the obesity boards this year.


I understand the future of medicine and the potential of personalized medicine to enhance disease cure and prevention. In this case, I have been able use my understanding of metabolic genetics, clinical genetics, bariatric medicine, pedigree analysis, mobile health, medicine and wellness, to help cure diabetes, hypertension and depression. It is amazing how people feel better when they are no longer obese.


I along with 2 other physicians, my 3 nurse practitioners and our 3 offices (yes, a long way from a genetic counselor and a part time office on Park Avenue, NYC) devote every day to early detection of disease and prevention of disease.


You will soon be able to see the fruits of our labors. We are modifying environment aggressively to overcome genetic and familial risks. We take family history, environmental history, genetic testing (if indicated), mobile health tools, technology, social history and use these tools to maximize human life.


A concept we call Arete (R-eh-Tee). The Sherpa is creating the best system to cure disease, using the model developed from his own 30 pounds of weight loss and journey to health. Come see us, we are still in Greenwich, 115 East Putnam Avenue, 23 Maple Avenue, 49 Lake Avenue. 203-869-0451.


The Sherpa Says: We have made camp, 1/3rd up the mountain, beans and lamb are on the fire, with quite an ascent coming. Genomes, Environmental, Technology. Coming soon! But for now, go buy Lee's book!



20 Aralık 2012 Perşembe

When you urge coercion by the government,don't be shocked if you get coerced as well

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The following quote explains the title.See here for further details


All people have the moral obligation to care for those who are less fortunate. But replacing morality with legality is the first step in replacing church, religion and conscience with government, politics and majority vote. Coercing people to feed the poor simply substitutes moral poverty for material poverty.
The bishops dance with the devil when they invite government to use its coercive power on their behalf, and there’s no clearer example than the Affordable Care Act. They happily joined their moral authority to the government’s legal authority by supporting mandatory health insurance. They should not have been surprised when the government used its reinforced power to require Catholic institutions to pay for insurance plans that cover abortions and birth control.
Dancing with the devil is dangerous business.

The corporate physician - he is not your father's doctor

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Dr. Roy Poses has tirelessly written about the loss of professionalism in the medical profession.Here is the link for a recent commentary by Dr. Poses about the rise and likely consequences of the corporate physician.

There was a time when the AMA vigorously opposed the corporate practice of medicine and a number of states outlawed it.But now times have changed and few states have strong statutes limiting it.

Texas still has a residual- but significantly watered down- corporate practice of Medicine statute. See here for a history of the corporate practice of medicine idea with emphasis on the exceptions even in Texas which has one of the strongest prohibitions against the corporate practice.In Texas the most widely used exception is the situation in which a "non-profit health corporation"-so certified according to defined statutory criteria-can hire physicians.See here for a discussion of what is referred to as a 501(a) entity.The rational of the original opposition to corporate practice was simply that the business entity would control the doctor's practice and profit-not the patients best interest would be controlling.There is much to suggest that the same objection is valid today but few voices are heard in that regard.It should be noted that the "non-profit health corporations" included the "not for profit hospitals". As is obvious Non-profit as well as successful for profit hospitals annually have revenue greater than cost;otherwise they would not be able to keep expanding with more and more branch offices and purchasing physician practices let alone keep operating.

Recently,  I attended a seminar sponsored by the local medical society  labelled as eligible for CME credit under the ethics category of required annual CME credit in Texas.The topic was how to promote your medical practice and , of course, advertizing was one way recommended.

There are at least two negative consequences of physician being employed by hospitals or large medical aggregations ( that includes the latest incarnation, the highly touted ACO):

1)Increased costs to the patient

2)decreased quality of care

Poses give illustrative examples of how the same procedure can cost more when ordered by or performed by a physician working for the hospital   versus a free standing doctor not compensated by the hospital. Read Dr. Poses's posting referenced above for details about these negative consequences.

People respond to incentives.Physicians employed by health care corporation inevitably will face the situation in which the incentives generated by corporate goals and targets with which the docs will be tasked  will conflict with  the primary directive ( or what used to be the prime directive ) of a physician namely doing what is right for the individual patient.I am afraid that the physician's role as a patient advocate  in the corporate health care organization may go the way of the AMA's prohibition against physicians advertizing,a quaint historical artifact.Once the physician accepts the new ethics position that they are responsible for the health of the collective ( the ACO may be the collective ),then the greater good for the greatest number will just happen to coincide with the financial health of the organization.

More social justice bubbles up from the magic Obamacare fountain

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There is so much social justice being dispensed from ACA that I can't really keep up. Here is one more instance,one that is imminent, ( Jan 1, 2013) the capping of health saving accounts at $ 2,500 down from 5,000 see here for Forbes article.

Twenty per cent of workers have HSAs.Meanwhile premiums rise on health insurance. So ACA forces folks to spend more on their health insurance and "nudging" them to spend less at their own discretion.

While this latest wrinkle is only a relatively small cog in the mammoth ACA legislation the progressive medical elite can savor it as it is one more move to limit the individual's choice in medical care which is the operational arm of their dominant theme which is "medical care is too important and complicated to be left to individual patient and his physician."

Affordable Care Act as a monumental Baptist and Bootlegger morality tale

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 "We are pattern-seeking,story-telling animals".

From chapter 1 , Macroeconomic Patterns and Stories, Edward E. Leamer


In a 1983 article in the journal Regulation, the economist Bruce Yandle introduced the concept of the Baptist and the Bootlegger (B+B). It refers to the situation in which a given legislation or regulatory action is supported by some group on high moral grounds as in denouncing the evils of alcohol.Support also comes another group who stand to get economic gain from that legislation such as bootleggers would if alcohol sales were banned. The Mafia rule of "follow the money" is useful in seeking out who might be the bootleggers in a given situation.See here for some classic examples of the B+B pattern including the acid rain story and the tale of  spotted owl.

After I became aware of the B+B pattern I seem to see it in many places, even in the Affordable Care Act.So here is the story.

I can see the medical progressives as the Baptists. Medical progressives believe (many of them sincerely) that health care or medical care is too complex,complicated and important to be left to the individual patient and his physician.Rather it should be determined by the elite who using a utilitarian ethic with the tools of cost effectiveness research will be able to find practices that will benefit society as a whole.But control is not the what the medical progressives explicitly argue for in their advocacy but rather it is the furtherance of the social justice that will be fulfilled as millions will now have access to health care and health care inequality will be greatly diminished. No, not  all physicians who  supported ACA  fall into that category.There are many sincere physicians who believe the statute is the way to obtain health care for  millions who are now under served and who are not part of the progressive medical elite but typically it is not their voice we hear from the pulpit.

I can see a coalition of bootleggers at work in the formulation of the many pages of dense, self referential legal prose that comprises ACA. The Mafia rule works well here.

Who would gain from millions of new clients with health care insurance?

Easy answers. The hospitals would gain simply as there would be many more  clients to be able to seek out and pay for their services. Similarly the big health insurance companies would welcome millions of more clients who are forced to pay for their product.Big Pharma would be in the position of more customers who could buy their products with other people's money. Information technology companies would relish the legislation to force or nudge physicians to buy and maintain computers systems.

But there is more.While the Baptists were singing hymns of praise for social justice,equality,elimination of waste, and the millions of uninsured Americans,the bootleggers and their lobbyists were busy working with the movers and deciders on the hill (eg. Max Baucus and his adviser, Elizabeth " revolving door" Fowler) to work out the important details. Big Pharma was able to get restrictions on the re importation of generic drugs,big hospital was able to be exempted from the actions of IPAB until 2020 and big health insurance was able to keep the public option from being included in the statute.

 Of course, metaphors and other figures of speech only can go so far,the reality flows over the cup.What about the medical professional organizations such as AMA, ACP, AAFP, etc.Many of these talked the talk of the preachers.Yet some had something to gain. The AMA  gathers more cash flow from its monopoly on coding than from the decreasing number of members' dues and coding will only increase as more patients are seen by physicians.Why did ACP and AAFP and others advocate for passage of Obamacare? Did they have anything to gain or were they merely dedicated preachers? Maybe the metaphor does not allow for much moral ambiguity.

The preacher who is pure in heart and sincere in belief gains only the satisfaction of doing the right thing.Preachers rarely have part time jobs as bootleggers or renounce the cloth and become a full time dealer in illegal sales of a prohibited substance. 

Folks with MD degrees who advocate for universal health care and alterations in medical ethics favorable to third party payers who either before or after that advocacy hold executive positions in major health insurance companies might gain more than self satisfaction. Maybe some people can really do well by doing good and that would be true in this instance if in fact passage of ACA is considered a good thing. Sometimes it is hard to tell the Baptists from the Bootleggers .






Expose of how big pharma worked on the sausage of Obamacare's social justice

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See here for a fascinating, detailed account of the behind the scenes activities in the creation of one part of the Affordable Care Act.

Details of the cahoot activities were gleaned from numerous E-mails studied by the House Energy and Commerce committee.

After an agreement was reached between PhRMA (the lobby group for big pharma) and the white house they donated 150 million for an ad campaign and another 70 million for two front groups to advocate for passage of the bill. Big Pharma was able to block efforts to allow re-importation of medications and to enable CMS to negotiate drug prices for medicare part D.

The WSJ on line article linked above includes this paragraph.

At least PhRMA deserves backhanded credit for the competence of its political operatives—unlike, say, the American Medical Association. A thread running through the emails is a hapless AMA lobbyist importuning Ms. DeParle and Mr. Messina for face-to-face meetings to discuss reforming the Medicare physician payment formula. The AMA supported ObamaCare in return for this "doc fix," which it never got.

 If the lobbyists for AMA were hapless, what can you say about the lobbyists for the medical device manufacturing sector? See here for an article indicating that now even liberal Democratic senators seem to belatedly realize that the tax on that sector will cause the loss of jobs .

Perhaps the Obamacare sausage maker who should be singled out for special recognition is Elizabeth Fowler who some (including Max Baucus who should know) have said is the real author of ACA. Another important aspect of the cahooting,crony capitalism,baptist and the bootlegger world of legislation is the revolving door aspect. See here for how flagrant that process can be with a detailed chronology of Dr. Fowler's resume.Here are comments in that regard by Glenn Greenwald,by whom very little gets by:


  Ms. Fowler “will receive ample rewards from that same industry as she peddles her influence in government and exploits her experience with its inner workings to work on that industry’s behalf, all of which has been made perfectly legal by the same insular, Versailles-like Washington culture that so lavishly benefits from all of this.”


h/t Dr. G.Keith Smith for reference to House Committee's report

16 Aralık 2012 Pazar

What's the Sherpa Up To?

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I have decided to write an update to what the Sherpa is Up To. Why? Well, after 5 years of hard work, Lee Gutkind is about to publish a work of creative nonfiction. I am one of the main characters. The other characters are also very compelling. 


I was able to preview a copy and am very excited. 


But, after reading, I thought I should give you an update on what the Sherpa is doing. Let me explain my madness. Here is my thought. As my good friend John Setaro MD would say. 


"There isn't any genetic advantage that can't be overcome with aggressive environmental modification."


This was me. I was overweight, the practice was stressing me and killing me. I needed to lose weight. I did. 30 pounds of weight. Mostly fat. This changed my life. How did I do it? FitBit, metabolic testing using gas exchange, calorie tracking, some things that a guy like Eric Topol MD would call mobile health.


I began to pay attention to obesity. I noticed that obesity is a huge familial disease and an epidemic in the US. But, the genetic markers soft at best. So I say again, family history matters more. I studied fat metabolism and began to realize this disease was very similar to some mitochondrial deficiencies. I began to align genetics, family history, obesity and preventative care. Truly personalized medicine. I will sit for the obesity boards this year.


I understand the future of medicine and the potential of personalized medicine to enhance disease cure and prevention. In this case, I have been able use my understanding of metabolic genetics, clinical genetics, bariatric medicine, pedigree analysis, mobile health, medicine and wellness, to help cure diabetes, hypertension and depression. It is amazing how people feel better when they are no longer obese.


I along with 2 other physicians, my 3 nurse practitioners and our 3 offices (yes, a long way from a genetic counselor and a part time office on Park Avenue, NYC) devote every day to early detection of disease and prevention of disease.


You will soon be able to see the fruits of our labors. We are modifying environment aggressively to overcome genetic and familial risks. We take family history, environmental history, genetic testing (if indicated), mobile health tools, technology, social history and use these tools to maximize human life.


A concept we call Arete (R-eh-Tee). The Sherpa is creating the best system to cure disease, using the model developed from his own 30 pounds of weight loss and journey to health. Come see us, we are still in Greenwich, 115 East Putnam Avenue, 23 Maple Avenue, 49 Lake Avenue. 203-869-0451.


The Sherpa Says: We have made camp, 1/3rd up the mountain, beans and lamb are on the fire, with quite an ascent coming. Genomes, Environmental, Technology. Coming soon! But for now, go buy Lee's book!



Dealing with other people's pregnancies

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This is something I've been asked about a few times, and something I was just thinking about, so thought I'd share. In the months after Joshua's death, some people were hesitant to tell us they were pregnant in case they upset us, some tell us before anyone else because they want to tell us in person rather than on the grapevine. That really didn't bother me, I'm generally excited to hear about friends pregnancies. Ultrasounds were hard to look at, and baby showers were hard to go to, and still are. Joshua died 2 days after our baby shower, so baby showers just don't have that same level of fun anymore, memories of our loss just come flooding back.

The other thing that's hard to deal with is other people's loss, but for a slightly different reason - my heart just aches for them. A very close friend had an early miscarriage a few months ago, and my heart ached for her. Another good friend who has also had a rough year has just suffered a 2nd trimester loss, and it breaks my heart. I don't want anyone to ever feel the weight of loss like we did. I know a loss earlier in the pregnancy is probably a bit easier to deal with, but it's never easy, and once you start planning names, planning how the room will look, what you'll need, changes you'll need to make, and start thinking about the future they're going to have, it's so hard to have it all ripped away.

It's something that really affects you for a long time, and I think it's important for people to understand that.

Catching up (yes I'm still alive)

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It's been a really busy few months! I'll go back to September.

We went on holiday to the Seychelles and Dubai for 2 weeks in September which was fabulous. My aunt Vicki lives there with her husband Chris and their two boys, Jack and Harry. Chris has a job as part of the United Nations, which is based in the Seychelles and they've been living there about 4 years now.

The Seychelles was fascinating. The economy is completely broken - they have the highest level of debt of any other country, and since we were there the International Monetary Fund has agreed on a $26 million rescue package, and the currency has floated and been devalued. A lot of things were run down, the roads were terrible, there's a big divide between the rich and poor and everything has to be imported, so the black market is rife.

But the beaches were gorgeous, the weather was fabulous, the sky was oh so clear at night, and the stars were stunning. Sitting out on Vicki and Chris' deck every evening watching the night sky was an amazing way to relax. We were a very short walk from the beach, and just enjoyed our 10 days there relaxing.

It was great to spend quality time with Vicki, Chris and the boys. Vicki lived with us for a few years when I was younger, so I've always felt very close to her, and Jack and Harry are such great kids, we had a lot of fun with them.

Here's a few pics from the trip:

The markets



Amazingly clear water



Full moon over the fishing boats that were at port due to the worries over the Somalian pirates



We hiked to a beach called Anse Major, which was quiet, and so pretty



On our way to Anse Major




View from Vicki and Chris' balcony



Everyone. Vicki doesn't usually look so grim, and no, Andrew didn't bother with shaving while away :)



A couple of gorgeous sunrises







After Seychelles we spent a few days in Dubai on the way home since we were flying with Emirates (best airline I've ever flown with by a long shot), and stopping in Dubai anyway.

It was Ramadan, so we couldn't eat or drink in public during daylight hours, and a number of places were either closed for the month, or closed for a few hours in the afternoon, but it wasn't a big deal. We had a really nice hotel which we got a great deal on due it being Ramadan, and therefore the low season, the city in general wasn't too busy, and we just did a double decker open top tour bus tour the 2 days we were there, which supplied us with complimentary cold bottles of water which we guzzled as soon as we got on the bus - so we probably drank more water than we would have otherwise.

It was stinking hot - over 40 c, and about 90% humidity, and the heat was disgustingly oppressive. We had a fabulous time though. It was such an interesting place, and there was so much to see and do. And being so hot, it made us very aware that we were in a desert, and the regular calls to prayer from the temples made the whole experience more authentic. It's a place I would like to go back to some time to further explore - 2 and a bit days definitely wasn't enough!

Some pics:

Down on the water - there were boats coming and going loading up with goods to be transported to other nearby countries, carrying tourists around, and general water taxis for transport.




A small selection of gold in one of the windows at the Gold Souk (market)



A shopping centre called Wafi - it had designer shops, and an upmarket "traditional" souk area - the place was deserted due to Ramadan, and most of the shops weren't opening the entire month.



One of the water taxis



Dubai is a construction zone! There were cranes everywhere you looked. The sky was never clear, it's pretty much one big sand storm. And this highway made American highways look tame!



The new Metro system they are building which will make a huge difference to traffic - you can see Burj Dubai in the background which will be the world's tallest building



In front of Burj Al Arab, Jumeirah - the water there was toasty warm!



And then Ski Dubai... so bizarre!



One of the big mosques



One of the mosques near us. They were having the evening iftar buffet (breaking of the daily fast)



And Andrew on Dubai Creek at sunset



The rest of the photos are here